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25-hydroxyvitamin D₃
25-hydroxyvitamin D₃

Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D₃, is a form of vitamin D produced in the liver by hydroxylation of vitamin D₃ by the enzyme vitamin D 25-hydroxylase.

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Introduction

Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D₃, is a form of vitamin D produced in the liver by hydroxylation of vitamin D₃ by the enzyme vitamin D 25-hydroxylase.

1.25% 25-hydroxyvitamin D₃

Product 25-Hydroxy Vitamin D3 Batch No 2203091
Specification ≥1.25% Quantity 1000kg
Mfg. Date 2022.03.09 Issu. Date 2022.03.10
Exp. Date 2024.03.08 Packing 25kg/carton
Quality Standard Q/JLBO 11-2021
Items Specification Results
[Appearance and character] white to yellow powder White powder
[Examining!
Granularity 100.0% pass through the sieve of 0.85mm More than 85.0% pass through the sieve of 0.425mm 100.0% pass through the sieve of 0.85mm 90.3% pass through the sieve of 0.425mm.
Loss on drying ≤5.0% 3.1%
Heavy metals 5mg/kg Complies
Total Arsenic 3mg/kg Complies
[Assay] Contains 25-Hydroxy Vitamin D3 31.25% 1.31%
Conclusion: The result meets the requirements of Q/JLBO11 -202

0.025% 25-hydroxyvitamin D₃

 

Product 25-Hydroxy Vitamin D3 Batch No 2203132
Specification ≥0.025% Quantity 1000kg
Mfg. Date 2022.03.13 Issu. Date 2022.03.14
Exp. Date 2024.03.12 Packing 25kg/carton
Quality Standard Q/JLB011-2021
Items Specification Results
[Appearance and character] white to yellow powder White powder
[Examining]
Granularity 100.0% pass through the sieve of 0.85mm More than 85.0% pass through the sieve of 0.425mm 100.0% pass through the sieve of 0.85mm 90.3% pass through the sieve of 0.425mm.
Loss on drying 5.0% 0.8%
Heavy metals 5mg/kg Complies
Total Arsenic 3mg/kg Complies
[Assay] Contains 25-Hydroxy Vitamin D3 30.025% 002^%—
Conclusion: The result meets the requirements of

 

Functions and Applications

25-hydroxyvitamin D3 have been used in some studies to improve vitamin D status. Indications for their use include vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia, hypoparathyroidism, hypocalcemia and renal osteodystrophy and, with calcium, in primary or corticosteroid-induced osteoporosis.

Calcifediol may have advantages over cholecalciferol for the correction of vitamin D deficiency states. Calcifediol is better absorbed from the intestine and has greater affinity for the vitamin-D-binding protein, both of which increase its bioavailability.

 

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