Colistin Sulfate Premix is primarily used to treat intestinal infections caused by Gram-negative rods and to treat infections caused by Pseudomonas aeruginosa resulting from burns and wounds. As a feed additive, it promotes growth.

Here are some clinical considerations for its use:

One of the key features of this drug is its low likelihood of inducing drug resistance, a characteristic unmatched by many other clinical drugs. This helps to minimize the development of drug resistance.

Another feature is its ability to neutralize endotoxins. It binds to lipopolysaccharides (LPS) produced by bacteria via its positively charged -NH2 to the negatively charged phosphate group on the LPS. Therefore, Colistin Sulfate Premix can eliminate bacterial endotoxins, inhibit the release and activity of bacterial endotoxins, making it an effective anti-endotoxin drug.

This drug is highly sensitive to Gram-negative bacteria. In susceptibility tests, its medium-sensitivity inhibition zone is equivalent to the high-sensitivity inhibition zone of other antibiotics.

When taken orally, it is barely absorbed in the intestines, indicating a significant effect in treating intestinal infections caused by Gram-negative bacteria (such as Escherichia coli, Salmonella, Proteus, and Pseudomonas aeruginosa).

This drug is a slow-acting bactericide that primarily acts on the bacterial cell membrane, increasing its permeability. In clinical use, this property can be combined with other drugs to rapidly destroy the bacterial cell membrane. When used in combination with other drugs, it significantly enhances their efficacy.

It wouldn't be an exaggeration to say that Colistin Sulfate Premix acts as a synergist for other drugs (many compound products contain Colistin Sulfate Premix, leveraging this property).

Combination Therapy for Treating Intestinal Diseases:

It can be combined with amoxicillin, lincomycin, etc., to treat bacterial enteritis, enterotoxic syndrome, etc.

Common formulations include: Colistin Sulfate Premix+ lincomycin; Colistin Sulfate Premix + amoxicillin + TMP (as TMP is not water-soluble, some simple processing is needed for use).

When treating enteritis, the efficacy of the same drug can vary significantly due to different administration methods. For the above two formulations, the daily dose should be divided into 2-3 administrations, with each administration interval not less than 3-4 hours, to avoid concentrating the medication in one drinking session.

Drug Combination Contraindications: When used clinically, co-administration with aminoglycoside drugs may cause muscle weakness and respiratory arrest. Avoid using them together. There are no contraindications for combination with other types of drugs.

When treating mixed infections of Mycoplasma and E. coli, it can be combined with erythromycin, tiamulin, etc.

When treating septicemic E. coli, it can be combined with quinolones, fluoroquinolones, cephalosporins, and phosphomycin, yielding remarkable results.

When combined with sulfonamide drugs, it is unparalleled in treating coccidiosis-induced enteritis compared to other intestinal drugs.

In summary, in clinical use, Colistin Sulfate Premix can be used as a synergist, enhancing the effects of other antibiotics. Its outstanding efficacy against Gram-negative bacteria and low propensity for inducing drug resistance should not be overlooked. Does this analysis give you a new understanding of this product?